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Table 4 KEGG pathways having two or more quantitated proteins for which evidence of differential change between baseline to 1-year concentration with E+P and E-alone was significant, with FDR < 0.05

From: Postmenopausal estrogen and progestin effects on the serum proteome

E+P Pathway Number quantified protein Pvaluea FDR
Porphyrin and chlorophyll metabolism 2 <0.001 <0.001
Dorsoventral axis formation 4 <0.001 <0.001
Motor signaling pathway 2 0.002 0.009
Pancreatic cancer 2 0.002 0.009
Focal adhesion 14 0.003 0.011
Bladder cancer 3 0.005 0.015
Renal cell carcinoma 3 0.009 0.023
Notch signaling pathway 5 0.011 0.024
Ether lipid metabolism 2 0.012 0.024
Long term depression 2 0.022 0.039
Regulation of actin cytoskeleton 8 0.025 0.041
Cytokine-cytokine receptor interaction 21 0.032 0.048
E-alone pathway    
Porphyrin and chlorophyll metabolism 2 <0.001 <0.001
GNRH signaling pathway 2 <0.001 <0.001
Ether lipid metabolism 2 0.001 0.011
Bladder cancer 3 0.002 0.016
  1. aFrom a regularized Hotelling T2 test.