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Table 3 Genes correlating with weight loss

From: Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

  Center 1 (n = 21) Center 2 (n = 13)
  Gene-chip    RT-qPCR   
Gene CC rectus abdominis CC rectus abdominis Regression P -value CC vastus lateralis Regression P -value CC diaphragm Regression P -value
APCDD1 -0.74 -0.51 0.03 0.26 NS -0.20 NS
CAMk2B 0.82 0.50 0.01 0.45 0.06 0.50 0.03
EIF3I 0.64 0.50 0.02 0.10 NS 0.20 NS
HGS 0.7 0.67 0.00 0.17 NS 0.20 NS
NUDC 0.65 0.72 0.00 0.13 NS 0.0 NS
POLRMT 0.6 0.51 0.02 0.07 NS 0.0 NS
TIE1 0.67 0.53 0.01 0.70 0.003 0.0 NS
TSC2 0.69 0.47 0.03 0.40 0.1 0.0 NS
  1. Significance analysis of microarrays (SAM) identified 82 genes correlating with weight loss. qRT-PCR validated eight of nine selected targets from this list (correlation coefficient (CC)). These eight genes were also examined in the cohort from center 2 using RNA extracted from anatomically distinct regions. For each gene the correlation coefficient from the Affymetrix data set is shown followed by the correlation coefficient for qRT-PCR and a P-value for this latter regression. NS: not significant.