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Table 2 Relative risks to relatives of affected individuals calculated within the stochastic simulation for Probit, CRisch and Odds models

From: Multi-locus models of genetic risk of disease

   Probit CRisch Odds
K λ MZ λ Sib λ MZ λ Sib λ MZ λ Sib
0.1 0.1 1.3 1.2 0.99 1.4 1.2 1.00 1.3 1.1 1.00
0.1 0.5 3.2 1.9 0.87 5.6 2.6 0.84 3.9 2.1 0.85
0.1 0.7 4.7 2.4 0.81 7.6 3.0 0.83 6.0 2.8 0.80
0.1 0.95 7.8 3.1 0.82 9.7 3.2 0.92 9.3 3.2 0.90
0.01 0.1 1.9 1.4 0.97 2.4 1.5 1.00 1.7 1.3 1.03
0.01 0.5 13.0 4.4 0.68 51.7 9.9 0.53 34.8 8.1 0.54
0.01 0.7 26.6 7.0 0.54 76.8 12.3 0.51 62.3 11.3 0.49
0.01 0.95 67.3 11.7 0.49 97.0 13.0 0.57 94.6 12.9 0.57
0.001 0.1 2.8 1.7 0.96 4.0 2.0 1.00 1.2 1.1 1.06
0.001 0.5 54.8 10.5 0.49 516.5 41.6 0.30 342.5 34.0 0.30
0.001 0.7 157.8 20.6 0.37 796.8 51.4 0.30 638.5 49.5 0.26
0.001 0.95 599.8 47.5 0.27 989.9 57.6 0.30 968.6 55.9 0.31
  1. is an input parameter for the Probit model. For each τ is estimated from the Probit model simulation and used as input to the CRisch and Odds model simulations. is used as the benchmark as τ is dependent on n, p and K.