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Table 4 Overview of in vivo delivery systems for snoRNAs and miRNAs*

From: Non-coding RNAs: a key to future personalized molecular therapy?

miRNA Disease state Biological target In vivomodel Delivery system References
miR-100 Nasopharyngeal cancer Plk1 6- to 8-week-old SCID BALB/c female mice siRNA and ionizing radiation and potential miRNAs that might regulate Plk1 expression [88]
Synthetic miR-16 Metastatic prostate cancer CDK1 and CDK2 Bone metastasis mode mice Injected into tail veins [89]
miR-155 Myeloproliferative disorder SHIP1 Mice, specific knockdown of SHIP1 in the hematopoietic system Retroviral delivery of a miR-155-formatted siRNA against SHIP1 [90]
SNORD116 (PWCR1/HBII-85) Prader-Willi syndrome Bioinformatic screen located 23 possible targets C57BL/6 mice Snord116del mice [21]
miR-147 Inflammation Cytokine expression in macrophages stimulated with ligands to Toll-like receptors: TLR2, TLR3, TLR4 LPS-stimulated mouse Peritoneal macrophages were transfected with 40 nM control miRNA mimics or mouse miR-147 mimics [91]
LNA-antimiR-122 Hypercholesterolemia miR-122 liver specific Normal and hypercholesterolemic mice; normal African green monkeys Intravenous injections unconjugated [62]
LNA-antimiR-21 Glioma miR-21 Athymic nude mice Intracranial cell implantation [92]
miR-34a Normal E2F family Nude mice Subcutaneous administration of miR-34a/collagen complexes [93]
mir-17-92 cluster Normal c-Myc Mice reconstituted with hematopoietic stem cells expressing mir-17-19b Perfusion cells treated by retroviral vector [94]
  1. *Abbreviations: CDK, cyclin-dependent kinase; E2F, E2 transcription factor; LPS, lipopolysaccharide; Plk1, Polo-like kinase 1; SCID, severe combined immunodeficient; SHIP1, Src homology-2 domain-containing inositol 5-phosphatase 1; TLR, Toll-like receptor.