Table 1 Example calculations of post-test probabilities
Type of disease and associated variants | Pre-test probability of disease (%) | Likelihood ratio | Post-test probability of disease (%) |
|---|---|---|---|
Common disease, weakly associated variant | 15.0 | 1.1 | 16.256 |
Common disease, several weakly associated variants | 15.0 | 1.1 × 1.1 × 1.1 × 1.1 = 1.46 | 20.486 |
Rare disease, weakly associated variant | 0.01 | 1.1 | 0.011 |
Rare disease, strongly associated variant | 0.01 | 5 | 0.050 |
Rare disease, several weakly associated variants | 0.01 | 1.1 × 1.1 × 1.1 × 1.1 = 1.46 | 0.015 |
Rare disease, several moderately associated variants | 0.01 | 2 × 2 × 2 × 2 = 16 | 0.160 |