Table 1 Relationship between clinical and biochemical characteristics and molecular groups of inflammation and fibrosis in infants with biliary atresia
From: Staging of biliary atresia at diagnosis by molecular profiling of the liver
Patient characteristic | Inflammation group, N = 15 | Fibrosis group, N = 26 | Total, N = 41a | P-valueb |
|---|---|---|---|---|
Sex, N (%) | Â | Â | Â | Â |
   Female | 6 (40) | 12 (46) | 18 (44) | 0.8 |
   Male | 9 (60) | 14 (54) | 23 (56) |  |
Race, N (%) | Â | Â | Â | Â |
   White | 11 (73) | 19 (73) | 30 (73) | 1.0 |
   Black | 1 (7) | 1 (4) | 2 (5) | 1.0 |
   Asian | 2 (13) | 1 (4) | 3 (7) | 0.5 |
   Other | 1 (7) | 5 (19) | 6 (15) | 0.6 |
Ethnicity, N (%) | Â | Â | Â | Â |
   Hispanic | 1 (7) | 1 (6) | 5 (12) | 0.6 |
   Nonhispanic | 14 (93) | 25 (94) | 36 (88) |  |
Age in days, median (25-75%) | 55 (46.3-63) | 71 (54-80) | 65 (50-75) | <0.01 |
Clinical type | Â | Â | Â | Â |
   BASM N (%) | 2 (13) | 3 (12) | 5 (12) | 1.0 |
   Perinatal N (%) | 13 (87) | 23 (88) | 36 (88) |  |
Mean CB at diagnosisc | 4.9 ± 2.1 | 5.8 ± 2.4 | 5.5 ± 2.3 | 0.3 |
Mean ALT at diagnosisc | 125 ± 83 | 154 ± 74 | 144 ± 78 | 0.3 |
Mean CB at 3 months after HPEc | 1.7 ± 2.6 | 3.5 ± 5.3 | 2.8 ± 4.5 | 0.3 |
Weight Z-score at 6 months after HPEc | -1.3 ± 1.1 | -1.7 ± 1.2 | -1.5 ± 1.2 | 0.4 |
Presence of cholangitis, N (%) | 8 (53) | 18 (72) | 26 (63) | 0.5 |
Presence of ascites, N (%) | 4 (27) | 12 (48) | 16 (40) | 0.3 |