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Table 1 Results of 11 single nucleotide polymorphisms selected for the risk model in the combined analysis of QTSCD and QTGEN

From: Novel genes for QTc interval. How much heritability is explained, and how much is left to find?

Locus Chromosome Variant Coded allele Beta Standard error Pvalue
RNF207 1 rs846111 C 1.70 0.21 3.69 × 10-16
NOS1AP 1 rs12143842 T 3.27 0.17 1.88 × 10-78
ATP1B1 1 rs10919071 A 1.78 0.22 1.20 × 10-15
SCN5A 3 rs12053903 C -1.23 0.12 1.0 × 10-14
PLN; C6orf204 6 rs11970286 T 1.53 0.15 2.35 × 10-24
KCNH2 7 rs4725982 T 1.44 0.16 5.0 × 10-16
KCNQ1 11 rs12296050 T 1.62 0.19 2.80 × 10-17
LITAF 16 rs8049607 T 1.34 0.17 5.78 × 10-15
NDRG4; CNOT1 16 rs37062 G -1.68 0.16 3.0 × 10-25
LIG3 17 rs2074518 T -1.05 0.12 6.0 × 10-12
KCNJ2 17 rs17779747 T -1.10 0.16 6.02 × 10-12
  1. The KCNE1 non-synonymous D85N variant rs1805128 (see also Figure 2) was not included in our risk score. It was genome-wide significant in the QTGEN study, but could not be confirmed in the QTSCD study and the combined analysis due to limited genotyping coverage in QTSCD.