Figure 1

Genomic structure of mir-21. Location of a previously described promoter (miPPR-21) [30], our putative regulatory region (GIS) [19], a H3K4me3 binding site as determined by previous ChIP-seq [32], and a STAT3 binding site according to Loffler et al. [34]. Both miPPR-21 and GIS regions are highly conserved.