Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Prentice, Ross L; Paczesny, Sophie; Aragaki, Aaron; Amon, Lynn M; Chen, Lin; Pitteri, Sharon J; McIntosh, Martin; Wang, Pei; Buson Busald, Tina; Hsia, Judith; Jackson, Rebecca D; Rossouw, Jacques E; Manson, JoAnn E; Johnson, Karen; Eaton, Charles; Hanash, Samir M

doi:10.1186/gm169

Table 1 Proteins having some evidence (P < 0.05) of difference in concentration between coronary heart disease cases and controls

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Protein	Description	Log(base2) case vs control ratio	P-value^a	FDR^a
B2M	Beta-2-microglobulin.	0.212	5.07e-05	0.0176
ORM1	Alpha-1-acid glycoprotein 1	0.120	0.000182	0.0315
IGFALS	Insulin-like growth factor-binding protein complex acid labile chain	-0.112	0.000384	0.0443
THBS1	Thrombospondin-1	-0.632	0.00133	0.0749
LPA	Apolipoprotein(A)	0.347	0.00138	0.0749
CFD	Complement factor D preproprotein	0.210	0.00141	0.0749
PRG4	Isoform C of proteoglycan 4	0.232	0.00152	0.0749
GPX3	Glutathione peroxidase 3	-0.224	0.00308	0.133
IGFBP1	Insulin-like growth factor-binding protein 1	0.423	0.00381	0.146
MST1	Hepatocyte growth factor-like protein homolog	-0.306	0.00592	0.205
ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2	-0.140	0.00786	0.247
ENO1	Isoform alpha-enolase of alpha-enolase	-0.418	0.00950	0.255
C9	Complement component C9	0.0827	0.00989	0.255
SFTPB	Pulmonary surfactant-associated protein B precursor	0.551	0.0112	0.255
FHL1	cDNA FLJ55259 highly similar to four and a half lim domains protein 1	-0.481	0.0116	0.255
CRISP3	cDNA FLJ75207	0.147	0.0118	0.255
SERPIND1	Serpin peptidase inhibitor clade D (heparin cofactor) member 1	0.210	0.0176	0.334
CD5L	CD5 antigen-like	0.152	0.0181	0.334
SOD3	Extracellular superoxide dismutase [Cu-Zn]	0.453	0.0183	0.334
TPI1	Triosephosphate isomerase 1 isoform 2	-0.144	0.0232	0.401
C1QB	Complement component 1 Q subcomponent B chain precursor	-0.106	0.0271	0.407
ATRN	Isoform 1 of attractin	-0.151	0.0274	0.407
INHBE	Inhibin beta E chain	0.384	0.0284	0.407
CHRDL2	Isoform 2 of chordin-like protein 2	-0.647	0.0287	0.407
LIMS1	cDNA FLJ55516 highly similar to particularly interesting new Cys-His protein	-0.412	0.0318	0.407
VASP	Vasodilator-stimulated phosphoprotein	-0.499	0.0356	0.407
C8A	Complement component C8 alpha chain	0.170	0.0359	0.407
C2	Complement C2 (fragment)	-0.230	0.0361	0.407
CD14	Monocyte differentiation antigen CD14	0.105	0.0361	0.407
GC	Vitamin D-binding protein	-0.0451	0.0364	0.407
MTPN	Myotrophin	-0.240	0.0372	0.407
SERPINF2	Serpin peptidase inhibitor, clade F, member 2	-0.110	0.0383	0.407
ACTA2	Actin aortic smooth muscle	-1.22	0.0388	0.407
TAGLN2	Transgelin-2	-0.186	0.0426	0.433
FERMT3	Isoform 2 of fermitin family homolog 3	-0.560	0.0462	0.454
F12	Coagulation factor XII	-0.147	0.0472	0.454
AFM	Afamin	-0.0764	0.0490	0.458

^aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate.

Back to article page

ISSN: 1756-994X

Contact us

Submission enquiries: editorial@genomemedicine.com
General enquiries: info@biomedcentral.com

Genome Medicine

Contact us