Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Prentice, Ross L; Paczesny, Sophie; Aragaki, Aaron; Amon, Lynn M; Chen, Lin; Pitteri, Sharon J; McIntosh, Martin; Wang, Pei; Buson Busald, Tina; Hsia, Judith; Jackson, Rebecca D; Rossouw, Jacques E; Manson, JoAnn E; Johnson, Karen; Eaton, Charles; Hanash, Samir M

doi:10.1186/gm169

Table 3 Proteins having some evidence (P < 0.05) of concentration difference between CHD cases and controls that are altered (P < 0.05) by postmenopausal hormone therapy

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

		CHD			E+P		E-alone
Protein	Description	Log(base2) case vs control ratio	P-value^a	FDR^a	Log(base2) case vs control ratio	P-value^a	Log(base2) case vs control ratio	P-value^a
B2M	Beta-2-microglobulin	0.212	5.07e-05	0.0176	0.208	0.00205	0.230	0.00110
IGFALS	Insulin-like growth factor-binding protein complex acid labile chain	-0.112	0.000384	0.0443	0.151	0.00785	0.143	0.0282
CFD	Complement factor D preproprotein	0.210	0.00141	0.0749	-0.246	0.00871	-0.0472	0.620
PRG4	Isoform C of proteoglycan 4	0.232	0.00152	0.0749	0.0735	0.181	0.128	0.0327
IGFBP1	Insulin-like growth factor-binding protein 1	0.423	0.00381	0.146	0.528	0.00242	1.270	3.66e-06
MST1	Hepatocyte growth factor-like protein homolog	-0.306	0.00592	0.205	0.530	0.0100	0.633	0.00195
C9	Complement component C9	0.0827	0.00989	0.255	0.101	0.0645	0.179	0.00858
SERPIND1	Serpin peptidase inhibitor clade D (heparin cofactor) member 1	0.210	0.0176	0.334	0.450	0.0240	0.156	0.344
C1QB	Complement component 1 Q subcomponent B chain precursor	-0.106	0.0271	0.407	0.0113	0.465	0.0480	0.0125
ATRN	Isoform 1 of attractin	-0.151	0.0274	0.407	-0.190	0.000213	-0.126	0.00366
INHBE	Inhibin beta E chain	0.384	0.0284	0.407	0.258	0.0723	0.520	0.00734
CHRDL2	Isoform 2 of chordin-like protein 2	-0.647	0.0287	0.407	-0.301	0.0415	-0.000906	0.993
C8A	Complement component C8 alpha chain	0.170	0.0359	0.407	-0.206	0.000163	-0.202	0.000121
C2	Complement C2 (fragment)	-0.230	0.0361	0.407	0.334	0.00371	0.291	0.0107
GC	Vitamin D-binding protein	-0.0451	0.0364	0.407	0.231	3.10e-06	0.237	2.75e-06
SERPINF2	Serpin peptidase inhibitor, clade F, member 2	-0.110	0.0383	0.407	0.0922	0.148	0.166	0.0247
F12	Coagulation factor XII	-0.147	0.0472	0.454	0.261	0.000102	0.252	0.000219
AFM	Afamin	-0.0764	0.0490	0.458	0.0580	0.119	0.177	0.000330

^aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate.

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