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Table 3 Proteins having some evidence (P < 0.05) of concentration difference between CHD cases and controls that are altered (P < 0.05) by postmenopausal hormone therapy

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

   CHD E+P E-alone
Protein Description Log(base2) case vs control ratio P-valuea FDRa Log(base2) case vs control ratio P-valuea Log(base2) case vs control ratio P-valuea
B2M Beta-2-microglobulin 0.212 5.07e-05 0.0176 0.208 0.00205 0.230 0.00110
IGFALS Insulin-like growth factor-binding protein complex acid labile chain -0.112 0.000384 0.0443 0.151 0.00785 0.143 0.0282
CFD Complement factor D preproprotein 0.210 0.00141 0.0749 -0.246 0.00871 -0.0472 0.620
PRG4 Isoform C of proteoglycan 4 0.232 0.00152 0.0749 0.0735 0.181 0.128 0.0327
IGFBP1 Insulin-like growth factor-binding protein 1 0.423 0.00381 0.146 0.528 0.00242 1.270 3.66e-06
MST1 Hepatocyte growth factor-like protein homolog -0.306 0.00592 0.205 0.530 0.0100 0.633 0.00195
C9 Complement component C9 0.0827 0.00989 0.255 0.101 0.0645 0.179 0.00858
SERPIND1 Serpin peptidase inhibitor clade D (heparin cofactor) member 1 0.210 0.0176 0.334 0.450 0.0240 0.156 0.344
C1QB Complement component 1 Q subcomponent B chain precursor -0.106 0.0271 0.407 0.0113 0.465 0.0480 0.0125
ATRN Isoform 1 of attractin -0.151 0.0274 0.407 -0.190 0.000213 -0.126 0.00366
INHBE Inhibin beta E chain 0.384 0.0284 0.407 0.258 0.0723 0.520 0.00734
CHRDL2 Isoform 2 of chordin-like protein 2 -0.647 0.0287 0.407 -0.301 0.0415 -0.000906 0.993
C8A Complement component C8 alpha chain 0.170 0.0359 0.407 -0.206 0.000163 -0.202 0.000121
C2 Complement C2 (fragment) -0.230 0.0361 0.407 0.334 0.00371 0.291 0.0107
GC Vitamin D-binding protein -0.0451 0.0364 0.407 0.231 3.10e-06 0.237 2.75e-06
SERPINF2 Serpin peptidase inhibitor, clade F, member 2 -0.110 0.0383 0.407 0.0922 0.148 0.166 0.0247
F12 Coagulation factor XII -0.147 0.0472 0.454 0.261 0.000102 0.252 0.000219
AFM Afamin -0.0764 0.0490 0.458 0.0580 0.119 0.177 0.000330
  1. aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate.