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Table 4 Proteins having some evidence (P < 0.05) of concentration difference between stroke cases and controls that are altered (P < 0.05) by postmenopausal hormone therapy

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

   Stroke E+P E-alone
Protein Description Log(base2) case vs control ratio P-valuea FDRa Log(base2) case vs control ratio P-valuea Log(base2) case vs control ratio P-valuea
APOA2 Apolipoprotein A-II -0.120 2.71e-05 0.00991 0.212 0.000532 0.302 1.75e-05
PPIA Peptidyl-prolyl cis-trans isomerase A 0.194 7.68e-05 0.0141 0.381 0.00899 0.201 0.126
IGFBP4 Insulin-like growth factor-binding protein 4 0.409 0.000320 0.0391 0.179 0.102 0.511 0.000697
F2 Prothrombin (fragment) -0.0732 0.000702 0.0642 0.0633 0.00366 0.0282 0.138
C6 Complement component 6 precursor -0.140 0.00227 0.138 -0.123 0.00151 -0.171 0.000123
LILRA3 Leukocyte immunoglobulin-like receptor subfamily A member 3 0.316 0.00341 0.177 -0.237 0.00874 -0.281 0.000277
HPX Hemopexin -0.0448 0.00407 0.177 0.123 6.65e-05 0.117 0.000124
IGFBP6 Insulin-like growth factor-binding protein 6 0.667 0.00435 0.177 0.0868 0.235 0.207 0.0158
IGFBP2 Insulin-like growth factor-binding protein 2 0.480 0.00609 0.189 -0.420 0.00477 -0.287 0.0317
GC Vitamin D-binding protein -0.0532 0.00699 0.189 0.231 3.10e-06 0.237 2.75e-06
CADM1 Isoform 1 of cell adhesion molecule 1 -0.199 0.00762 0.189 -0.0139 0.875 0.180 0.0249
COL1A1 Collagen alpha-1(I) chain 0.195 0.00826 0.189 -0.896 5.40e-07 -0.575 8.80e-05
COL6A3 Isoform 1 of collagen alpha-3(VI) chain 0.828 0.0109 0.210 -0.197 0.00852 -0.0134 0.834
RNASE1 Ribonuclease pancreatic 0.582 0.0143 0.243 0.0346 0.311 0.0953 0.0427
ITIH4 Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4 -0.238 0.0187 0.265 0.458 0.000733 0.374 0.00495
KLKB1 Plasma kallikrein -0.115 0.0202 0.270 0.252 0.00208 0.230 0.00187
B2M Beta-2-microglobulin 0.0728 0.0280 0.310 0.208 0.00205 0.230 0.00110
SERPINC1 Antithrombin-III -0.0631 0.0312 0.325 -0.196 5.05e-06 -0.143 5.50e-05
FCN3 Isoform 1 of ficolin-3 0.132 0.0323 0.325 0.0351 0.0287 0.0357 0.0333
HGFAC Hepatocyte growth factor activator -0.592 0.0324 0.325 -0.191 0.0979 -0.308 0.00765
RBP4 Retinol-binding protein 4 0.0478 0.0346 0.325 0.167 0.000117 0.177 0.000262
CFHR5 Complement factor H-related 5 -0.0800 0.0348 0.325 0.179 0.000264 0.241 2.76e-05
PRDX2 Peroxiredoxin-2 -0.533 0.0361 0.325 0.691 0.0201 -0.0266 0.925
C8A Complement component C8 alpha chain -0.179 0.0373 0.325 -0.206 0.000163 -0.202 0.000121
FETUB Fetuin-B 0.0662 0.0410 0.332 0.783 1.09e-09 0.741 1.02e-09
  1. aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate.