Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

Prentice, Ross L; Paczesny, Sophie; Aragaki, Aaron; Amon, Lynn M; Chen, Lin; Pitteri, Sharon J; McIntosh, Martin; Wang, Pei; Buson Busald, Tina; Hsia, Judith; Jackson, Rebecca D; Rossouw, Jacques E; Manson, JoAnn E; Johnson, Karen; Eaton, Charles; Hanash, Samir M

doi:10.1186/gm169

Table 4 Proteins having some evidence (P < 0.05) of concentration difference between stroke cases and controls that are altered (P < 0.05) by postmenopausal hormone therapy

From: Novel proteins associated with risk for coronary heart disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling

		Stroke			E+P		E-alone
Protein	Description	Log(base2) case vs control ratio	P-value^a	FDR^a	Log(base2) case vs control ratio	P-value^a	Log(base2) case vs control ratio	P-value^a
APOA2	Apolipoprotein A-II	-0.120	2.71e-05	0.00991	0.212	0.000532	0.302	1.75e-05
PPIA	Peptidyl-prolyl cis-trans isomerase A	0.194	7.68e-05	0.0141	0.381	0.00899	0.201	0.126
IGFBP4	Insulin-like growth factor-binding protein 4	0.409	0.000320	0.0391	0.179	0.102	0.511	0.000697
F2	Prothrombin (fragment)	-0.0732	0.000702	0.0642	0.0633	0.00366	0.0282	0.138
C6	Complement component 6 precursor	-0.140	0.00227	0.138	-0.123	0.00151	-0.171	0.000123
LILRA3	Leukocyte immunoglobulin-like receptor subfamily A member 3	0.316	0.00341	0.177	-0.237	0.00874	-0.281	0.000277
HPX	Hemopexin	-0.0448	0.00407	0.177	0.123	6.65e-05	0.117	0.000124
IGFBP6	Insulin-like growth factor-binding protein 6	0.667	0.00435	0.177	0.0868	0.235	0.207	0.0158
IGFBP2	Insulin-like growth factor-binding protein 2	0.480	0.00609	0.189	-0.420	0.00477	-0.287	0.0317
GC	Vitamin D-binding protein	-0.0532	0.00699	0.189	0.231	3.10e-06	0.237	2.75e-06
CADM1	Isoform 1 of cell adhesion molecule 1	-0.199	0.00762	0.189	-0.0139	0.875	0.180	0.0249
COL1A1	Collagen alpha-1(I) chain	0.195	0.00826	0.189	-0.896	5.40e-07	-0.575	8.80e-05
COL6A3	Isoform 1 of collagen alpha-3(VI) chain	0.828	0.0109	0.210	-0.197	0.00852	-0.0134	0.834
RNASE1	Ribonuclease pancreatic	0.582	0.0143	0.243	0.0346	0.311	0.0953	0.0427
ITIH4	Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4	-0.238	0.0187	0.265	0.458	0.000733	0.374	0.00495
KLKB1	Plasma kallikrein	-0.115	0.0202	0.270	0.252	0.00208	0.230	0.00187
B2M	Beta-2-microglobulin	0.0728	0.0280	0.310	0.208	0.00205	0.230	0.00110
SERPINC1	Antithrombin-III	-0.0631	0.0312	0.325	-0.196	5.05e-06	-0.143	5.50e-05
FCN3	Isoform 1 of ficolin-3	0.132	0.0323	0.325	0.0351	0.0287	0.0357	0.0333
HGFAC	Hepatocyte growth factor activator	-0.592	0.0324	0.325	-0.191	0.0979	-0.308	0.00765
RBP4	Retinol-binding protein 4	0.0478	0.0346	0.325	0.167	0.000117	0.177	0.000262
CFHR5	Complement factor H-related 5	-0.0800	0.0348	0.325	0.179	0.000264	0.241	2.76e-05
PRDX2	Peroxiredoxin-2	-0.533	0.0361	0.325	0.691	0.0201	-0.0266	0.925
C8A	Complement component C8 alpha chain	-0.179	0.0373	0.325	-0.206	0.000163	-0.202	0.000121
FETUB	Fetuin-B	0.0662	0.0410	0.332	0.783	1.09e-09	0.741	1.02e-09

^aP-value = significance level for no difference in protein concentration; FDR = estimated false discovery rate.

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