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Table 1 Mechanisms of resistance to sunitinib and everolimus

From: Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

Potential mechanisms of sunitinib resistance
   Hypoxia resistance of RCC cells
   Vascular resistance to VEGFR and PDGFR inhibition by sunitinib
Potential mechanisms of everolimus resistance
   Resistance of RCC cells to direct anti-proliferative everolimus effects
   Resistance of HIF1α target gene expression to repression by everolimus
   Hypoxia resistance of RCC cells
   Vascular resistance to VEGF pathway inhibition
  1. PDGFR, platelet derived growth factor receptor; RCC, renal cell carcinoma; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.