Figure 1

A representation of (a) Affymetrix 250 k SNP microarrays and (b) fluorescent in situ hybridization (FISH) that were used to identify a region of duplication containing the SNCA gene (highlighted by the box). (a) Relative copy number estimates for SNCA duplication are plotted against physical genomic position on chromosome 4. Raw data are shown that have not been normalized with respect to integers. (b) FISH was performed on interphase cells with three labeled SNCA probes directed at the entire locus (PAC 27M07, green), at the promoter and at intron 4 fragments (red).