Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned

Table 4 Genome-wide association studies on stroke

					Positive association
Population	Sample size	Sample size in replication	Number of SNPs examined	Number of SNPs examined in replication	Gene	Variant	Platform	References
Caucasian	1164 cases, 18438 controls	3656 cases, 3,613 controls	2,194,468	2	Near NINJ2 and WNK1	rs11833579, rs12425791	Affymetrix, Illumina	[111]
Japanese	992 cases, 5349 controls	705 cases, 3,426 controls	520,000	100	CELSR1 (*604523)	rs6007897, rs4044210	Affymetrix	[110]
Caucasian	1,661 cases, 10,815 controls	2,224 cases, 2,583 controls or 2,327 cases, 16,760 controls	310,881	120	Near PITX2 (*601542)	rs2200733, rs10033464	Illumina	[107]
US	249 cases, 268 controls	-	408,000	-	IMPA2 (605922), KCNIP4* (608182), KCNK17* (*607370)	rs7506045	Illumina	[106]

CELSR1, cadherin EGF LAG seven-pass G-type receptor 1; IMPA2, inositol(myo)-1(or 4)-monophosphatase 2; KCNIP4, Kv channel interacting protein 4; KCNK17, potassium channel, subfamily K, member 17; NINJ2, Nerve injury-induced protein 2; PITX2, paired-like homeodomain 2.

ISSN: 1756-994X