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Table 4 Genome-wide association studies on stroke

From: Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned

      Positive association   
Population Sample size Sample size in replication Number of SNPs examined Number of SNPs examined in replication Gene Variant Platform References
Caucasian 1164 cases, 18438 controls 3656 cases, 3,613 controls 2,194,468 2 Near NINJ2 and WNK1 rs11833579, rs12425791 Affymetrix, Illumina [111]
Japanese 992 cases, 5349 controls 705 cases, 3,426 controls 520,000 100 CELSR1 (*604523) rs6007897, rs4044210 Affymetrix [110]
Caucasian 1,661 cases, 10,815 controls 2,224 cases, 2,583 controls or 2,327 cases, 16,760 controls 310,881 120 Near PITX2 (*601542) rs2200733, rs10033464 Illumina [107]
US 249 cases, 268 controls - 408,000 - IMPA2 (*605922), KCNIP4 (*608182), KCNK17 (*607370) rs7506045 Illumina [106]
  1. CELSR1, cadherin EGF LAG seven-pass G-type receptor 1; IMPA2, inositol(myo)-1(or 4)-monophosphatase 2; KCNIP4, Kv channel interacting protein 4; KCNK17, potassium channel, subfamily K, member 17; NINJ2, Nerve injury-induced protein 2; PITX2, paired-like homeodomain 2.