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Table 3 Effect estimates of 18 established susceptibility variants on type 2 diabetes risk in two studies

From: Genome-based prediction of common diseases: methodological considerations for future research

   Odds ratio (95% confidence interval)*
Gene Locus GoDARTS study [11] Rotterdam study [14]
TCF7L2 rs7903146 1.36 (1.24, 1.48) 1.31 (1.19, 1.44)
KCNJ11 rs5219 1.25 (1.15, 1.36) 1.03 (0.93, 1.13)
CDKN2A/2B rs10811661 1.21 (1.08, 1.35) 1.10 (0.98, 1.24)
PPARG rs1801282 1.21 (1.07, 1.36) 1.09 (0.95, 1.24)
ADAM30/NOTCH2 rs2641348 1.15 (1.01, 1.30) 1.01 (0.88, 1.17)
CDKN2A/2B rs564398 1.13 (1.04, 1.22) 1.04 (0.95, 1.14)
IGF2BP2 rs4402960 1.12 (1.03, 1.22) 1.11 (1.01, 1.22)
FTO rs8050136 1.11 (1.02, 1.20) 1.09 (0.99, 1.19)
CDKAL1 rs10946398§ 1.11 (1.02, 1.21) 1.11 (1.02, 1.22)
SLC30A8 rs13266634 1.10 (1.01, 1.20) 1.13 (1.02, 1.24)
TSPAN8/LGR5 rs7961581 1.09 (1.00, 1.19) 1.09 (0.99, 1.20)
CDC123 rs12779790¥ 1.10 (0.99, 1.21) 0.95 (0.84, 1.06)
WFS1 rs10010131** 1.07 (0.99, 1.16) 1.12 (1.05, 1.27)
TCF2 rs757210†† 1.07 (0.99, 1.16) 0.93 (0.85, 1.02)
ADAMTS9 rs4607103‡‡ 1.05 (0.96, 1.16) 1.14 (1.03, 1.28)
HHEX-IDE rs1111875 1.02 (0.94, 1.11) 1.06 (0.97, 1.15)
THADA rs7578597 1.04 (0.90, 1.19) 1.10 (0.96, 1.27)
JAZF1 rs864745§S 1.00 (0.93, 1.09) 1.09 (1.00, 1.19)
  1. *AUC (area under the receiver operating characteristic curve) was 0.60 for both studies. Values were obtained using logistic regression analyses. For several genes, the Rotterdam study [14] uses different single nucleotide polymorphisms from those listed: ‡‡rs4411878, r2 = 0.95; ¥rs11257622; r2 = 0.83; rs1412829, r2 = 0.97; §Srs1635852, r2 = 0.97; rs1493694; rs1353362, r2 = 0.96; ††rs4430796, r2 = 0.61; **rs10012946, r2 = 1.00; §rs7754840, r2 = 1.00. Statistically significant associations are presented in bold and r2 is a measure of linkage disequilibrium.