Genomic risk factors in sudden infant death syndrome

Table 1 Summary of SIDS-associated gene studies and implicated genes

Pathway	Total number of studies	Studies with positive genotype association or mutations implicated	Mean cohort size (range)	Genes independently verified [references]
Central nervous system	20	13	85 (20 to 172)	5-HTT [15, 21–23]
Cardiac channelopathies	16	13	141 (6 to 292)	KCNQ1, KCNH2, SCN5A [50, 52, 101, 102]
Immune dysfunction	20	10	103 (16 to 250)	IL6, IL10, C4A, C4B [70, 71, 73, 75, 77, 82, 83]
Metabolism/energy	23	5	178 (2 to 1304)	Mitochondrial D-loop, MCAD [85, 86, 90, 91]
Nicotine response	2	1	106, 159	None

ISSN: 1756-994X