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Table 1 MiRNAs involved in addiction

From: New insights into the roles of microRNAs in drug addiction and neuroplasticity

Drug miRNAs involved Mechanisms affected References
Cocaine miR-212 Decreases activity of CREB and TORC1, and controls expression of gene encoding BDNF via interaction with MeCP2 [4, 15]
  miR-181a Upregulated by cocaine; affects expression of genes encoding BDNF, DAT, CREB, Homer1 and Drd3 [10, 11]
  let-7d Downregulated by cocaine; targets semaphorins, BDNF, neuropilins and mGluR5 [10, 11]
  miR-124 Downregulated by cocaine; targets Drd3, DAT and FosB [10, 11]
  miR-324-5p Induced by Arg2 in Drd2 neurons; regulates cdk5r1, FosB and Mef2d [5, 9]
  miR-369-3p Induced by Arg2 in Drd2 neurons; regulates cdk5r1, FosB and Mef2d [5, 9]
Nicotine miR-140 Induced by nicotine; regulates dynamin-1, regulates synaptic endocytosis [12, 16]
  miR-504 Upregulates gene encoding Drd1 [12, 16]
Opiates miR-23b Induces mOR [19]
  miR-190 Induced by mOR by upregulation of talin2 [13, 19]
  miR-15b, miR-181b Induced by morphine [20, 21]
   Induced by morphine  
  miR-133b Decreased by morphine; this increases expression of gene encoding Pitx3 and induces TH and DAT [6]
Antidepressants, alcohol and CYP3A4 miR-133b Specifically expressed in dopaminergic neurons; downregulates expression of gene encoding Pitx3; Pitx3 induces production of TH and DAT and regulates maturation of midbrain dopaminergic neurons [6, 21]
  miR-16 Induced by SSRI in serotonergic neurons; reduces expression of gene encoding SERT [23]
  miR-9 Induced by alcohol; downregulates BK channels [4]
  miR-212 Induced by alcohol; decreases ZO-1, affects cell permeability [22]
  miR-27b Downregulates CYP3A4 [17]
  miR-298 Downregulates CYP3A4 [17, 24]
  1. Arg2, arginase, type II; cdk5r1, cyclin-dependent kinase 5, regulatory subunit 1; CREB, cAMP-responsive element binding protein; BDNF, brain-derived neurotrophic factor; CYP3A4, cytochrome P450 3A4; DAT, dopamine transporter; Drd1, dopamine receptor D1R; Drd2, dopamine receptor D2R; Drd3, dopamine receptor D3R; FosB, FBJ murine osteosarcoma viral oncogene homolog B; MeCP2, methyl CpG binding protein 2; Mef2 d, myocyte enhancer factor 2D; mGluR5, metabotropic glutamate receptor 5; SSRI, selective serotonin reuptake inhibitor; TH, tyrosine hydroxylase; TORC1, transducer of regulated CREB activity 1; ZO-1, tight junction protein.