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Table 3 Top significant markers (-Log 10(p) > 6)) after adjusting for DRB1*15:0 1 among the 700-independent-gene set

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

rs ID

Position

Chrom.

Gene name

Allele 1

Allele 2

-Log10 p

OR

Lower CL

Upper CL

rs9268148

32367505

6

C6orf10

A

G

13.13

0.58

0.50

0.67

rs1611715

29937461

6

HLA-G

C

A

11.49

0.74

0.68

0.81

rs7772297

31436805

6

HLA-B

C

G

9.14

1.40

1.26

1.56

rs4939490

60550227

11

CD6

G

C

9.00

1.30

1.19

1.42

rs9275596

32789609

6

HLA-DQA2

T

C

7.85

0.76

0.69

0.84

rs10244467

22584456

7

IL6

T

C

7.23

0.57

0.47

0.70

rs9596270

49740441

13

DLEU1

T

C

7.08

1.56

1.31

1.85

rs12025416

116750329

1

CD58

C

T

6.83

0.69

0.59

0.80

rs6836440

100405684

4

ADH4

A

G

6.74

0.68

0.58

0.79

rs7137953

119357405

12

GATC

C

T

6.47

0.77

0.70

0.85

rs10846336

16413619

12

MGST1

T

C

6.43

0.42

0.30

0.59

rs931555

35839334

5

IL7R

C

T

6.41

1.25

1.15

1.36

rs10203141

179015804

2

OSBPL6

C

G

6.40

0.81

0.75

0.88

rs2328523

20575342

6

E2F3

G

A

6.28

0.79

0.72

0.87

rs4368946

98497864

8

TSPYL5

T

C

6.25

0.70

0.61

0.80

rs3934035

281714

3

CHL1

C

T

6.23

0.46

0.34

0.62

rs17062281

73654880

13

KLF12

C

G

6.13

0.44

0.31

0.61

rs1356122

155666264

3

GPR149

G

C

6.13

1.26

1.14

1.40

rs4447

31599694

22

SYN3

T

C

6.10

0.74

0.66

0.83

rs655763

108682027

11

C11orf87

C

T

6.03

1.59

1.32

1.92

rs12419184

125561518

11

RPUSD4

C

T

6.03

0.72

0.63

0.82

  1. Chrom., chromosome; lower CL, lower bound of the confidence interval; OR, odds ratio; upper CL, upper bound of the confidence interval.