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Table 5 Clinical and demographic characteristics of various genetic-load groups

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

  Genetic-load groups by the level of estimated cumulative genetic risk
  High Medium Low Misclassified  
Clinical and demographic variables P-Hat = 0.95 P-Hat = 0.75-0.95 P-Hat = 0.5-0.75 P-Hat < 0.5 Test
Sample size, N (%) 383 (39.6%) 313 (32.3%) 142 (14.7%) 130 (13.4%)  
MSSS (least-square mean)a 1.77 1.82 1.83 1.81 F = 0.41, P = 0.75c
T2-lesion load (mm3) (least-square mean)b 15.41 15.40 14.32 15.81 F = 0.98, P = 0.40c
Age of disease onset (years) 33.81 33.55 33.18 35.90 F = 2.71, P = 0.03d
DRB1*15:01 +, N (%) 242 (63.2%) 146 (46.7%) 51 (35.9%) 31 (23.9%) χ2 = 74.13e
DRB1*15:01 -, N (%) 141 (36.8%) 167 (53.4%) 91 (64.1%) 99 (76.1%) P < 0.0001
Female, N (%) 285 (74.4%) 206 (65.8%) 85 (59.9%) 68 (52.3%) χ2 = 25.41e
Male, N (%) 98 (25.6%) 107 (34.2%) 57 (40.1%) 62 (47.7%) P < 0.0001
  1. aMSSS (Multiple Sclerosis Severity Score [44]) after square-root transformation to meet normality assumption. bT2-lesion volumes after cube-root transformation to meet normality assumption. cANCOVA test result, with 'age of disease onset' and gender as covariates. dANCOVA test result, with gender as covariate.
  2. eChi-square test result.