Table 5 Clinical and demographic characteristics of various genetic-load groups
From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data
| Â | Genetic-load groups by the level of estimated cumulative genetic risk | ||||
|---|---|---|---|---|---|
| Â | High | Medium | Low | Misclassified | Â |
Clinical and demographic variables | P-Hat = 0.95 | P-Hat = 0.75-0.95 | P-Hat = 0.5-0.75 | P-Hat < 0.5 | Test |
Sample size, N (%) | 383 (39.6%) | 313 (32.3%) | 142 (14.7%) | 130 (13.4%) | Â |
MSSS (least-square mean)a | 1.77 | 1.82 | 1.83 | 1.81 | F = 0.41, P = 0.75c |
T2-lesion load (mm3) (least-square mean)b | 15.41 | 15.40 | 14.32 | 15.81 | F = 0.98, P = 0.40c |
Age of disease onset (years) | 33.81 | 33.55 | 33.18 | 35.90 | F = 2.71, P = 0.03d |
DRB1*15:01 +, N (%) | 242 (63.2%) | 146 (46.7%) | 51 (35.9%) | 31 (23.9%) | χ2 = 74.13e |
DRB1*15:01 -, N (%) | 141 (36.8%) | 167 (53.4%) | 91 (64.1%) | 99 (76.1%) | P < 0.0001 |
Female, N (%) | 285 (74.4%) | 206 (65.8%) | 85 (59.9%) | 68 (52.3%) | χ2 = 25.41e |
Male, N (%) | 98 (25.6%) | 107 (34.2%) | 57 (40.1%) | 62 (47.7%) | P < 0.0001 |