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Table 7 The percentage of variance (R2) explained by predictors in the regression model

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

  Center Gender DRB1*15:01 12 genesa 350 genesb
The discovery dataset (n = 8,844) 15% 4% 7% 10% 57%
The validation dataset (n = 3,606) NA 2% 9% 11% (AUCc = 0.68) 27% (AUCc = 0.769)
  1. aThe 12-gene set includes HLA-DRB1 and 11 additional validated genes. bThe 350-gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile. cAUC, area under curve from ROC analysis results.