Figure 2

Dependency network in schizophrenia and related psychoses. The network was constructed from the diagnostic, clinical, antipsychotic medication use, and metabolite cluster data. Node shapes represent different types of variables and platforms, node color corresponds to significance and direction of regulation (schizophrenia versus controls), and line width is proportional to strength of dependency. The two metabolic variables directly linked with schizophrenia and two other metabolic network hubs are highlighted with green squares. The cutoff for the presence of an edge was set at β = 0.25 by the average non-rejection rate, that is, an edge in the graph was tested positive in 25% of the 500 samplings. Abbreviations: BDI, Beck Depression Inventory [26]; BMI, body mass index; Chol, cholesterol; CRP, C-reactive protein; DiastBP, diastolic blood pressure; GGT, gamma-glutamyltransferase; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment index; LDL, low-density lipoprotein; NIDDM, non-insulin-dependent diabetes mellitus; SystBP, systolic blood pressure; TG, total triglycerides; Tot, total.