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Table 1 Genome alterations reported in published whole genome studies

From: Genome interrupted: sequencing of prostate cancer reveals the importance of chromosomal rearrangements

Tumor type Number of tumors sequenced Approximate number of point mutations per tumor Average number of non-synonymous mutations per tumor Number of rearrangements per tumor Reference(s)
Lung (non-small-cell) 1 50,000 302 43 Lee et al. (2010) [8]
Melanoma 1 30,000 187 74 Pleasance et al. (2010) [2]
Lung (small-cell) 1 20,000 94 58 Pleasance et al. (2010) [3]
Breast 2 6,000 ~30 40 Ding et al. (2010) [4]; Shah et al. (2009) [9]
Prostate 7 4,000 20 ~100 Berger et al. (2011) [1]
AML 1 1,000 8 ND Mardis et al. (2009) [5]
  1. AML, acute myelogenous leukemia; ND, not determined.