Table 1 Genome alterations reported in published whole genome studies
Tumor type | Number of tumors sequenced | Approximate number of point mutations per tumor | Average number of non-synonymous mutations per tumor | Number of rearrangements per tumor | Reference(s) |
|---|---|---|---|---|---|
Lung (non-small-cell) | 1 | 50,000 | 302 | 43 | Lee et al. (2010) [8] |
Melanoma | 1 | 30,000 | 187 | 74 | Pleasance et al. (2010) [2] |
Lung (small-cell) | 1 | 20,000 | 94 | 58 | Pleasance et al. (2010) [3] |
Breast | 2 | 6,000 | ~30 | 40 | |
Prostate | 7 | 4,000 | 20 | ~100 | Berger et al. (2011) [1] |
AML | 1 | 1,000 | 8 | ND | Mardis et al. (2009) [5] |