From: Future medical applications of single-cell sequencing in cancer
Cancer | Heterogeneity | Method | Details | Reference |
---|---|---|---|---|
Lung | Morphology | H&E staining | Microscopic examination | [67] |
Pancreas | Morphology | H&E staining | Microscopic examination | [68] |
Prostate | Morphology | H&E staining | Microscopic examination | [69] |
Bladder | Morphology | H&E staining | Microscopic examination | [70] |
Glioma | DNA | G-banding | G-banding and ploidy | [23] |
Breast | DNA | G-banding | Karyotype G-banding | [25] |
Breast | DNA | G-banding | Karyotype G-banding | [27] |
Breast | DNA | G-banding | Karyotype G-banding | [94] |
Bladder | DNA | FISH | DNA copy number analysis | [26] |
Breast | DNA | FISH | DNA copy number analysis | [72] |
Pancreas | DNA | FISH | DNA copy number analysis | [74] |
Neuroblastoma | DNA | FISH | DNA copy number analysis | [73] |
Breast | DNA | FISH | DNA copy number analysis | [28] |
Multiple myeloma | DNA | FISH | DNA copy number analysis | [75] |
Esophagus | DNA | FISH | FISH, LOH, microsatellites, sequencing | [76] |
Breast | DNA | FISH | DNA copy number analysis | [71] |
Breast (DCIS) | Protein | IHC | IHC using antibodies | [52] |
Breast | Protein | MS | MS and LCM | [84] |
Prostate | RNA | Expression | Transcriptional microarrays | [82] |
Cervix | RNA | Expression | Transcriptional microarrays | [83] |
Breast | DNA | CGH | LCM and BAC-CGH | [78] |
Breast | DNA | CGH | Receptor-purification and SNP microarrays | [3] |
Breast | DNA | CGH | Sectoring and aCGH | [2] |
Breast | DNA | CGH | Sectoring, ploidy and aCGH | [1] |
Cervix | DNA | CGH | Regional macrodissection and aCGH | [79] |
Breast | DNA | NGS | NGS | [80] |
Breast | DNA | NGS | NGS | [81] |
Pancreas | DNA | NGS | Sectoring and NGS | [77] |
Breast | DNA | NGS | Single-nucleus sequencing | [10] |