Correlation between the oTIN subtype and expression levels of splicing factors. (a) Pearson correlation coefficients (r) for the 151 splicing factors with expression levels significantly correlated to the total relative amounts of deviating exon usage (P < 0.05). Shown with grey bars are significantly correlated genes representing the median from 100 randomly selected gene sets of equal size (n = 102). Plotted below is the expression level versus deviating exon usage amounts per sample for the splicing factor gene with the strongest correlation (HNRNPUL1, r = -0.63, both axes are median-centered and log-2 transformed). (b) The splicing factor gene set has more genes (n = 151) significantly correlated to the total relative amounts of deviating exon usage than each of 100 random gene sets (range 84 to 124). (c) The splicing factor gene set has more genes with significant negative correlation to deviating exon usage amounts, and fewer genes with significant positive correlation, compared to 100 random gene sets.