Transcriptome instability in the colorectal cancer validation series. (a) Sample-wise comparison of deviating exon skipping and inclusion events for the 77 CRCs in the validation series. (b) Patients in the validation series whose tumors where characterized with both sTIN and oTIN had a significantly lower 5-year disease-specific survival rate than patients whose tumors were characterized with none or only one of the two TIN subtypes. Deaths from CRC were considered events (n = 10). Censoring occurred at 5 years for survivors (n = 61), and at time of incidence for causes of death other than CRC (n = 6). Recurrences among survivors (n = 9) were ignored.