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Table 1 Clinicopathological and molecular characteristics of the two independent colorectal cancer study populations

From: Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival

  Test series (n= 83) Validation series (n= 77)
Age at diagnosis (mean ± SD) 66.0 ± 11.7 72.7 ± 13.5
Sex (male; female) 40; 43 33; 44
Stage (II; III) 46; 37 44; 33
Location (right; left; rectum) 26; 25; 32 46; 20; 11
Mean follow-up, years (minimum; maximum) 6.7 (0.7; 10.0) 3.5 (0.2; 5.0)
Number of events (deaths from CRC) 41 10
MSI 13 24
sTINa 12 (15%) 24 (31%)
oTINb 14 (17%) 30 (39%)
Either sTIN, oTIN, or both 24 (29%) 43 (56%)
Both TIN phenotypes 2 (2%) 11 (14%)
  1. asTIN, skewed transcriptome instability; preferential exon inclusion or skipping (difference in relative amounts of aberrant exon skipping and inclusion greater than ± 0.7). boTIN, overall transcriptome instability; total relative amounts of aberrant splicing greater than ± 1.0. SD, standard deviation; TIN, transcriptome instability.