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Table 3 Breast cancer odds ratio for WHI trial interventions by genotype of MRPS3 0 SNP rs7705343

From: Genetic variants in the MRPS30 region and postmenopausal breast cancer risk

   SNP genotype  
   GG GA AA  
Intervention Number of cases ORa 95% CI ORa 95% CI ORa 95% CI P-valueb
E-alone 247 0.484 (0.306, 0.766) 0.974 (0.684, 1.387) 0.969 (0.508, 1.846) 0.043
E+P 471 1.404 (1.003, 1.965) 1.248 (0.966, 1.613) 1.303 (0.858, 1.980) 0.863
DMQ 428 0.524 (0.360, 0.761) 0.862 (0.651, 1.141) 1.023 (0.643, 1.627) 0.042
CaD 1,049 0.763 (0.613, 0.951) 1.071 (0.902, 1.271) 1.049 (0.791, 1.391) 0.046
  1. aOR, estimated intervention odds ratio; bP-value, significance level for SNP interaction with clinical trial intervention. CI, confidence interval; WHI, Women's Health Initiative.