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Table 1 Genes most strongly associated with fAD and sAD*

From: Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges

Gene AD type Product Function or pathway ID method Reference(s)
APP Familial Amyloid precursor protein Cell surface receptor, vesicle trafficking, cell signaling Pedigree [79, 80]
PSEN1 Familial Presenilin 1 Proteolytic subunit of γ-secretase Pedigree [10]
PSEN2 Familial Presenilin 2 Proteolytic subunit of γ-secretase Pedigree [8, 9]
APOE Sporadic Apolipoprotein E Apoprotein, catabolism of triglyceride-rich lipoprotein constituents, endocytosis Candidate, GWAS [8183]
CLU Sporadic Clusterin (Apolipoprotein J) Secreted chaperone Candidate, GWAS [21, 22, 84]
PICALM Sporadic Phosphatidylinositol-binding clathrin assembly protein Clathrin assembly, endocytosis GWAS [21]
EXOC3L2 Sporadic Exocyst complex component 3-like 2 Unclear GWAS [23]
BIN1 Sporadic Bridging integrator 1 (amphiphysin II) Nucleocytoplasmic adaptor protein, possible role in synaptic vesicle endocytosis GWAS [23]
CR1 Sporadic Complement receptor 1 Complement cascade regulation GWAS [22]
SORL1 Sporadic Sortilin-related receptor Low density lipoprotein receptor family member, possible role in endocytosis and sorting Candidate [85]
GWA_14q32.13 Sporadic Unknown Unclear GWAS [86]
TNK1 Sporadic Tyrosine kinase, non-receptor 1 Nonreceptor tyrosine kinase GWAS [86]
IL8 Sporadic Interleukin 9 CXC chemokine family member, mediation of inflammatory response Candidate [87]
  1. *Top 10 results from AlzGene database [78], accessed March, 2011.