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Table 1 Genes most strongly associated with fAD and sAD*

From: Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges

Gene

AD type

Product

Function or pathway

ID method

Reference(s)

APP

Familial

Amyloid precursor protein

Cell surface receptor, vesicle trafficking, cell signaling

Pedigree

[79, 80]

PSEN1

Familial

Presenilin 1

Proteolytic subunit of γ-secretase

Pedigree

[10]

PSEN2

Familial

Presenilin 2

Proteolytic subunit of γ-secretase

Pedigree

[8, 9]

APOE

Sporadic

Apolipoprotein E

Apoprotein, catabolism of triglyceride-rich lipoprotein constituents, endocytosis

Candidate, GWAS

[81–83]

CLU

Sporadic

Clusterin (Apolipoprotein J)

Secreted chaperone

Candidate, GWAS

[21, 22, 84]

PICALM

Sporadic

Phosphatidylinositol-binding clathrin assembly protein

Clathrin assembly, endocytosis

GWAS

[21]

EXOC3L2

Sporadic

Exocyst complex component 3-like 2

Unclear

GWAS

[23]

BIN1

Sporadic

Bridging integrator 1 (amphiphysin II)

Nucleocytoplasmic adaptor protein, possible role in synaptic vesicle endocytosis

GWAS

[23]

CR1

Sporadic

Complement receptor 1

Complement cascade regulation

GWAS

[22]

SORL1

Sporadic

Sortilin-related receptor

Low density lipoprotein receptor family member, possible role in endocytosis and sorting

Candidate

[85]

GWA_14q32.13

Sporadic

Unknown

Unclear

GWAS

[86]

TNK1

Sporadic

Tyrosine kinase, non-receptor 1

Nonreceptor tyrosine kinase

GWAS

[86]

IL8

Sporadic

Interleukin 9

CXC chemokine family member, mediation of inflammatory response

Candidate

[87]

  1. *Top 10 results from AlzGene database [78], accessed March, 2011.