Sensitivity, specificity, and positive and negative predictive value (PPV, NPV) for different frequencies of the population at high risk. The frequency of the population at high risk is defined as the proportion of individuals with a number of risk alleles equal to or higher than the chosen threshold. The graphs in the upper row show the sensitivity and PPV for all possible risk thresholds, and the graphs in the lower row the specificity and NPV. Genetic risk scores are based on 50 genetic risk variants. The OR indicates the value of the odds ratio for each risk variant. Disease risk is 30%.