Sensitivity and positive predictive value (PPV) when the frequency of the high-risk group is lower than, equal to or higher than the disease risk. The frequency of the high-risk group is defined as the proportion of individuals with a number of risk alleles equal to or higher than the chosen threshold. (a-c) High-risk groups have a frequency of 5% (a), 30% (b) and 50% (c). Five to 600 variants are included in the genetic risk models to obtain an increase in the AUC. Each risk variant has a frequency of 30% and OR of 1.1. Disease risk is 30%.