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Table 3 Evidence for heritability of radiosensitivity as a human trait

From: Genetics and genomics of radiotherapy toxicity: towards prediction

Study population Assay* Heritability (%) Reference
16 Radiosensitive breast cancer survivors and 37 first-degree relatives, 4 breast cancer survivors with normal radiosensitivity and 15 first-degree relatives G2 82 [41]
23 Cancer survivors, 29 partners, 38 offspring, 27 controls G2 67 [76]
148 Monozygotic and 57 dizygotic twin pairs; 50 siblings Apoptosis 63 [77]
199 Father, mother, offspring trios Apoptosis 61 [78]
38 Dizygotic and 16 monozygotic twin pairs Apoptosis; cell cycle delay 68; 59 [40]
29 Cancer survivors, 29 partners, 53 offspring G2 58 to 78 [79]
39 Monozygotic and 10 dizygotic twin pairs MN 68 [42]
  1. *Peripheral blood lymphocytes were used in all studies. The G2 assay involves scoring chromosome damage in cells irradiated in G2 phase of the cell cycle. The micronucleus (MN) assay involves irradiating cells and preventing progression through mitosis. Radiation-damaged chromosomes form micronuclei that are counted.