Genetics and genomics of radiotherapy toxicity: towards prediction

West, Catharine M; Barnett, Gillian C

doi:10.1186/gm268

Table 5 SNPs and risk of radiotherapy toxicity

From: Genetics and genomics of radiotherapy toxicity: towards prediction

Gene(s) investigated	Cancer	Number	Association(s)	Reference
21	Esophageal	81	XRCC2, GSTP1	[87]
TP53	Lung	253	Yes	[88]
XRCC1	Prostate	603	Yes	[89]
XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, MGMT	Breast	87	XRCC1, XRCC3, MSH2	[90]
59	NSCLC	173	PTGS22, IL1A, IL8, TNF, MIF, NOS3	[91]
XRCC1, OGG1, MRCC3	Breast	43	No	[92]
TGFB1, XRCC1, XRCC2	Head and neck	60	TGFB1, XRCC1, No. risk alleles	[93]
XRCC1	Breast	119	Yes	[94]
ATM	Lung	253	Yes	[95]
ATM, GSTP1, SOD2, XPD, XRCC1	Breast	69	No. risk alleles	[96]
211	Cervix	243	NPAT-ATM, AURKA	[97]
TGFB1, L10P, C509T, G915C	Breast	190	No	[98]
TGFB1	Breast	778	No	[99]
MC1R	Mixed	30	Yes	[100]
APEX1, XRCC1, XRCC2, XRCC3, XPD, TP53, P21	Breast	409	TP53	[101]
TGFB1	NSCLC	164	Yes	[102]
XRCC3, RAD51, XRCC5, LIG4, XRCC6	Head and neck	88	XRCC3, XRCC6	[103]
XRCC1, APEX1, OGG1, XRCC2, XRCC3, NBN, XPA, ERCC1, XPC, TP53, P21, MDM2	Prostate	405	No	[104]
TGFB1	Prostate	445	No	[105]
GSTA1, GSTM1, GSTT1, GSTP1, MPO, SOD2, NOS3, CAT	Breast	390	GSTA1, NOS3	[52]
VEGF	Prostate	99	Yes	[106]
TGFB1	Prostate	141	Yes	[107]
3,144 SNPs in 494 genes	Breast	156	Associations	[108]
SOD2, XRCC1, XRCC3	Prostate	135	XRCC1, SOD2, SOD2+XRCC3	[109]
ATM, SOD2, XRCC1, XRCC3, TGFB1, RAD21	Mixed severe reactors	30	No. risk alleles	[39]
TP53, CDKN1A	Breast	22	No	[110]
450 SNPs in 115 genes	Prostate	197	SART1, ID3, EPDR1, PAH, XRCC6	[111]
999 SNPs in 137 genes	Breast	399	CD44, MAD2L2, PTTG1, RAD9A, LIG3	[69]
TGFB1, XRCC1, APE1, DHFR, CX3CR1, MTHFR, EPHX1	Breast	167	XRCC1, TGFB1	[112]
ATM	Breast	252	Yes	[113]
GSTM1, GSTP1, GSTT1	Breast	253	GSTP1	[114]
CAT, SOD2, MPO, NOS3	Breast	446	No	[115]
XRCC1	Breast	247	Yes	[116]
TP53, p21	Breast	446	No	[117]
XRCC3, XRCC2, NBS1	Breast	446	No	[118]
TGFB1	Gynae	78	No	[119]
49	Prostate	83	LIG4, ERCC2, CYP2D6	[120]
TGFB1, SOD2, XRCC1, XRCC3, APEX, ATM	Breast	120	No	[59]
GSTA1, GSTP1, GSTM1, GSTT1	Breast	446	GSTP1	[121]
ERCC4	Head and neck	130	Yes	[122]
XRCC1, APE1, XPD	Breast	446	XRCC1, APE1	[123]
TGFB1, SOD2, XRCC1, XRCC3, APEX, ATM	Breast	52	TGFB1	[124]
XRCC1, XRCC3, OGG1	Gynae	62	No. risk alleles	[125]
XRCC1	Breast	254	Yes	[126]
TGFB1	Breast	103	Yes	[127]
TGFB1, SOD2, XRCC1, XRCC3, APEX	Breast	41	No. risk alleles	[128]
ATM	Breast	254	Yes	[129]
SOD2	Breast	80	No	[130]
RAD21	Mixed	19	Yes	[131]

Gynae, cervix and endometrial cancer; No. risk alleles, number of homozygous rare and heterozygous alleles for the various SNPs studied; NSCLC, non-small cell lung cancer, SNP, single nucleotide polymorphism.

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ISSN: 1756-994X

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