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Table 5 SNPs and risk of radiotherapy toxicity

From: Genetics and genomics of radiotherapy toxicity: towards prediction

Gene(s) investigated Cancer Number Association(s) Reference
21 Esophageal 81 XRCC2, GSTP1 [87]
TP53 Lung 253 Yes [88]
XRCC1 Prostate 603 Yes [89]
XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, MGMT Breast 87 XRCC1, XRCC3, MSH2 [90]
59 NSCLC 173 PTGS22, IL1A, IL8, TNF, MIF, NOS3 [91]
XRCC1, OGG1, MRCC3 Breast 43 No [92]
TGFB1, XRCC1, XRCC2 Head and neck 60 TGFB1, XRCC1, No. risk alleles [93]
XRCC1 Breast 119 Yes [94]
ATM Lung 253 Yes [95]
ATM, GSTP1, SOD2, XPD, XRCC1 Breast 69 No. risk alleles [96]
211 Cervix 243 NPAT-ATM, AURKA [97]
TGFB1, L10P, C509T, G915C Breast 190 No [98]
TGFB1 Breast 778 No [99]
MC1R Mixed 30 Yes [100]
APEX1, XRCC1, XRCC2, XRCC3, XPD, TP53, P21 Breast 409 TP53 [101]
TGFB1 NSCLC 164 Yes [102]
XRCC3, RAD51, XRCC5, LIG4, XRCC6 Head and neck 88 XRCC3, XRCC6 [103]
XRCC1, APEX1, OGG1, XRCC2, XRCC3, NBN, XPA, ERCC1, XPC, TP53, P21, MDM2 Prostate 405 No [104]
TGFB1 Prostate 445 No [105]
GSTA1, GSTM1, GSTT1, GSTP1, MPO, SOD2, NOS3, CAT Breast 390 GSTA1, NOS3 [52]
VEGF Prostate 99 Yes [106]
TGFB1 Prostate 141 Yes [107]
3,144 SNPs in 494 genes Breast 156 Associations [108]
SOD2, XRCC1, XRCC3 Prostate 135 XRCC1, SOD2, SOD2+XRCC3 [109]
ATM, SOD2, XRCC1, XRCC3, TGFB1, RAD21 Mixed severe reactors 30 No. risk alleles [39]
TP53, CDKN1A Breast 22 No [110]
450 SNPs in 115 genes Prostate 197 SART1, ID3, EPDR1, PAH, XRCC6 [111]
999 SNPs in 137 genes Breast 399 CD44, MAD2L2, PTTG1, RAD9A, LIG3 [69]
TGFB1, XRCC1, APE1, DHFR, CX3CR1, MTHFR, EPHX1 Breast 167 XRCC1, TGFB1 [112]
ATM Breast 252 Yes [113]
GSTM1, GSTP1, GSTT1 Breast 253 GSTP1 [114]
CAT, SOD2, MPO, NOS3 Breast 446 No [115]
XRCC1 Breast 247 Yes [116]
TP53, p21 Breast 446 No [117]
XRCC3, XRCC2, NBS1 Breast 446 No [118]
TGFB1 Gynae 78 No [119]
49 Prostate 83 LIG4, ERCC2, CYP2D6 [120]
TGFB1, SOD2, XRCC1, XRCC3, APEX, ATM Breast 120 No [59]
GSTA1, GSTP1, GSTM1, GSTT1 Breast 446 GSTP1 [121]
ERCC4 Head and neck 130 Yes [122]
XRCC1, APE1, XPD Breast 446 XRCC1, APE1 [123]
TGFB1, SOD2, XRCC1, XRCC3, APEX, ATM Breast 52 TGFB1 [124]
XRCC1, XRCC3, OGG1 Gynae 62 No. risk alleles [125]
XRCC1 Breast 254 Yes [126]
TGFB1 Breast 103 Yes [127]
TGFB1, SOD2, XRCC1, XRCC3, APEX Breast 41 No. risk alleles [128]
ATM Breast 254 Yes [129]
SOD2 Breast 80 No [130]
RAD21 Mixed 19 Yes [131]
  1. Gynae, cervix and endometrial cancer; No. risk alleles, number of homozygous rare and heterozygous alleles for the various SNPs studied; NSCLC, non-small cell lung cancer, SNP, single nucleotide polymorphism.