Table 3 Prognostic hypoxia gene expression signatures in breast cancer

Chi et al. [65]

Signature of hypoxia upregulated genes in epithelial cells in vitro: 253 genes

MFS HR = 2.164

Death HR = 2.387

0.004

0.003

Seigneuric et al. [67]

Early signature of hypoxia: 15 genes

DSS HR = NR

< 0.05

Winter et al. [47]

Signature of hypoxia-related genes in HNSCC: 99 genes

NKI data set:

MFS HR = 2.83

< 0.001

Buffa et al. [63]

Common signature of hypoxia-related genes in HNSCC and breast cancer in vivo: 51 genes

NKI data set:

MSF HR = 4.15

GSE2034 data set:

RFS HR = 3.22

GSE3494 data set:

DSS HR = 3.16

0.002

0.001

0.042

Buffa et al. [103]

Reduced common signature of hypoxia-related genes in HNSCC and breast cancer: NK genes

NKI data set:

MSF HR = 5.58 (NK = 3)

GSE2034 data set:

RFS HR = 4.15

(NK = 10)

GSE3494 data set:

DSS HR = 4.27

(NK = 2)