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Table 3 Prognostic hypoxia gene expression signatures in breast cancer

From: Gene expression and hypoxia in breast cancer

Study Description and size of gene signature Hazard ratio (HR) P-value
Chi et al. [65] Signature of hypoxia upregulated genes in epithelial cells in vitro: 253 genes MFS HR = 2.164
Death HR = 2.387
0.004
0.003
Seigneuric et al. [67] Early signature of hypoxia: 15 genes DSS HR = NR < 0.05
Winter et al. [47] Signature of hypoxia-related genes in HNSCC: 99 genes NKI data set:
MFS HR = 2.83
< 0.001
Buffa et al. [63] Common signature of hypoxia-related genes in HNSCC and breast cancer in vivo: 51 genes NKI data set:
MSF HR = 4.15
GSE2034 data set:
RFS HR = 3.22
GSE3494 data set:
DSS HR = 3.16
0.002
0.001
0.042
Buffa et al. [103] Reduced common signature of hypoxia-related genes in HNSCC and breast cancer: NK genes NKI data set:
MSF HR = 5.58 (NK = 3)
GSE2034 data set:
RFS HR = 4.15
(NK = 10)
GSE3494 data set:
DSS HR = 4.27
(NK = 2)
< 0.001
< 0.001
0.006
  1. DSS, disease-specific survival; GSE, genomic special event; MSF, metastasis-free survival; NK, number of genes; NKI, Netherlands Cancer Institute; NR, not reported; RFS, recurrence-free survival.