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Table 1 Demographic characteristics of chronic hepatitis C patients after therapy

From: Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

  Demographic factorsa
   Gender   
  Mean years of age (SD) Females Males Mean BMI (SD) Viral loadc
Australian cohort (n = 312,313)      
SVR (n = 130) 40.0 a (9.6) 52 b (40.0) 78 b (60.0) 26.927.0 (4.85.1) P = NS
NSVR (n = 182,183) 44.5 4 a (7.12) 42 43 b (23.15) 140 b (76.95) 27.4 (5.32)  
Berlin cohort (n = 310,307)      
SVR (n = 150,149) 41.0 (10.5) 79 78 (52.73) 71 (47.37) 25.1 (4.5) P < 0.05001
NSVR (n = 15,860) 46.7 8 (10.34) 69 68 (43.10) 91 90 (55.97.0) 25.9 (3.9)  
Newcastle UK cohort (n = 6,990)      
SVR (n = 3,140) 3837.2 a (11.86) 9 12 (29.030.0) 22 28 (7170.0) 25.23.7 (3.96.3) P ≤ 0.05002
NSVR (n = 5,038) 46.0 a (1210.0) 10 12 (26.324.0) 28 38 (73.776.0) 26.227.0 (6.64.8)  
Bonn cohort (n = 57)      
SVR (n = 26) 44.7 (12.9) 11 (42.3) 15 (57.7) 25.4 (4.23) P ≤ 0.05008
NSVR (n = 31) 50.8 (10.9) 11 (35.5) 20 (64.5) 27.3 (4.6)  
Trent UK cohort (n = 4,843)      
SVR (n = 2,221) 39.843.5 (9.80) 6 5 (27.323.8) 16 (72.776.2) 26.97.1 (3.57) NS
NSVR (n = 2,622) 45.747.4 (7.99.3) 5 4 (1918.2) 21 18 (8081.8) 2526.0 (2.93.5)  
Turin cohort (n = 11,495)      
SVR (n = 5,845) 41.63.3 (13.10) 28 18 (48.340.0) 30 27 (51.760.0) 24.023.9 (3.23) P ≤ 0.0502
NSVR (n = 5,650) 45.1 7 (10.09.7) 19 (33.938.0) 37 31 (66.162.0) 24.5 6 (3.34)  
Total cohort (n = 910,905)      
SVR (n = 417,411) 40.9 6 a (10.87) 185 176 b (44.442.8) 232 235 b (55.657.2) 25.5 7 (4.75) P < 0.05001
NSVR (n = 493,494) 45.7b 8 a (9.32) 156b 157 b (31.68) 337 b (68.42) 26.3 5 (4.76)  
  1. aP < 0.001 comparisons between responders (SVR) and non-responders (NSVR) based on Student's t-testUnless otherwise specified, mean (s.d.) are presented. bP < 0.05 005 comparisons between responders (SVR) and non-responders (NSVR) based on the χ2 test. cComparisons between SVR and NSVR based on the Mann-Whitney U test.