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Table 2 Table of haplotypes with odds ratios

From: Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

NUMBER

HAPLOTYPE

HAPLOTYPE TAGGING SNPA

FREQUENCY (%)

RESPONDERS (%)

NON-RESPONDERS (%)

P-VALUE

ORB (95% CI)

1

ATTGATCCTCTG

rs8109886

43.2

48.4

39.6

4.00 × 10-4

0.70 (0.57-0.85)

2

GCCAGCTGTAGA

rs8099917/rs7248668

23.8

16.5

30.4

9.51 × 10-11

2.20 (1.72-2.80)

3

GCTAGCTCCATG

rs10853727

10.3

10.1

10.6

0.77

1.04 (0.75-1.43)

4

ATTGATCCTATG

 

9.8

12.3

7.8

2.40 × 10-3

0.60 (0.43-0.83)

5

ATTAACTCTATG

 

1.9

2.2

1.7

0.47

0.79 (0.39-1.60)

6

GCCAGCTGTATG

 

1.4

1.1

1.6

0.39

1.49 (0.62-3.56)

  1. The distribution of the six haplotypes in haplotype block 2 (Fig 4) bound by SNPs rs12980275 and rs7248668. The order is: rs12980275, rs12982533, rs8105790, rs688187, rs11881222, rs8103142, rs12979860, rs48031221, rs10853727, rs8109886, rs8099917, rs7248668. aSNP in the haplotype block 2 that tag the respective haplotypes. bORs have been calculated as carriage of the haplotype vs non-carriage of the haplotype.