|
NUMBER
|
HAPLOTYPE
|
HAPLOTYPE TAGGING SNPA
|
FREQUENCY (%)
|
RESPONDERS (%)
|
NON-RESPONDERS (%)
|
P-VALUE
|
ORB (95% CI)
|
|---|
|
1
|
ATTGATCCTCTG
|
rs8109886
|
43.2
|
48.4
|
39.6
|
4.00 × 10-4
|
0.70 (0.57-0.85)
|
|
2
|
GCCAGCTGTAGA
|
rs8099917/rs7248668
|
23.8
|
16.5
|
30.4
|
9.51 × 10-11
|
2.20 (1.72-2.80)
|
|
3
|
GCTAGCTCCATG
|
rs10853727
|
10.3
|
10.1
|
10.6
|
0.77
|
1.04 (0.75-1.43)
|
|
4
|
ATTGATCCTATG
| |
9.8
|
12.3
|
7.8
|
2.40 × 10-3
|
0.60 (0.43-0.83)
|
|
5
|
ATTAACTCTATG
| |
1.9
|
2.2
|
1.7
|
0.47
|
0.79 (0.39-1.60)
|
|
6
|
GCCAGCTGTATG
| |
1.4
|
1.1
|
1.6
|
0.39
|
1.49 (0.62-3.56)
|
- The distribution of the six haplotypes in haplotype block 2 (Fig 4) bound by SNPs rs12980275 and rs7248668. The order is: rs12980275, rs12982533, rs8105790, rs688187, rs11881222, rs8103142, rs12979860, rs48031221, rs10853727, rs8109886, rs8099917, rs7248668. aSNP in the haplotype block 2 that tag the respective haplotypes. bORs have been calculated as carriage of the haplotype vs non-carriage of the haplotype.
