Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

Table 2 Table of haplotypes with odds ratios

NUMBER	HAPLOTYPE	HAPLOTYPE TAGGING SNP^A	FREQUENCY (%)	RESPONDERS (%)	NON-RESPONDERS (%)	P-VALUE	OR^B (95% CI)
1	ATTGATCCTCTG	rs8109886	43.2	48.4	39.6	4.00 × 10^-4	0.70 (0.57-0.85)
2	GCCAGCTGTAGA	rs8099917/rs7248668	23.8	16.5	30.4	9.51 × 10^-11	2.20 (1.72-2.80)
3	GCTAGCTCCATG	rs10853727	10.3	10.1	10.6	0.77	1.04 (0.75-1.43)
4	ATTGATCCTATG		9.8	12.3	7.8	2.40 × 10^-3	0.60 (0.43-0.83)
5	ATTAACTCTATG		1.9	2.2	1.7	0.47	0.79 (0.39-1.60)
6	GCCAGCTGTATG		1.4	1.1	1.6	0.39	1.49 (0.62-3.56)

The distribution of the six haplotypes in haplotype block 2 (Fig 4) bound by SNPs rs12980275 and rs7248668. The order is: rs12980275, rs12982533, rs8105790, rs688187, rs11881222, rs8103142, rs12979860, rs48031221, rs10853727, rs8109886, rs8099917, rs7248668. ^aSNP in the haplotype block 2 that tag the respective haplotypes. ^bORs have been calculated as carriage of the haplotype vs non-carriage of the haplotype.