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Table 3 Prediction of failure to clear of virus on therapy with PegIFN/R with homozygote non-responder SNPs (based on 404 responders and 464 non responders of European origin)

From: Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

Genotype Sensitivity (95% CI) Specificity (95% CI) Positive predictive value (95% CI) Negative predictive value (95% CI)
rs4803221 GG 8.4 (6.0-11.4) 97.0 (94.7-98.5) 77.1 (62.7-88.0) 47.1 (43.5-50.7)
rs7248668 AA 8.1 (5.7-11.0) 97.3 (95.1-98.7) 78.3 (63.6-89.1) 47.0 (43.4-50.5)
rs8099917 GG 7.4 (5.2-10.3) 96.8 94.5-98.3) 73.3 (58.1-85.4) 46.8 (43.2-50.4)
rs12979860 TT 18.9 (15.4-23.0) 89.5 (85.9-92.5) 68.3 (59.2-76.5) 48.0 (44.2-51.8)