From: Stem cell approaches for diabetes: towards beta cell replacement
Type | Protein | Description |
---|---|---|
MODY 1 | HNF4A | Loss-of-function mutations |
MODY 2 | Glucokinase | Many forms, most often mild diabetes, can cause hypoglycemia |
MODY 3 | HNF1A | Loss-of-function mutations |
MODY 4 | PDX1 | Pancreas atrophy and beta cell impairment |
MODY 5 | HNF1B | Pancreas atrophy and renal disease |
MODY 6 | NeuroD1 | Transcription factor important for beta cell development |
Permanent neonatal diabetes | KCNJ11, ABCC8, neurogenin 3 | Can be associated with hypoglycemia or diabetes. Some forms can be treated with sulfonylureas |
Transient neonatal diabetes | ABCC8 | Some forms remit with time |