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Figure 3 | Genome Medicine

Figure 3

From: Classification of unknown primary tumors with a data-driven method based on a large microarray reference database

Figure 3

Cancer-specific genes. (a) Tissue specificity scores, unmodified by gene weight, for genes whose weight in renal cancer is greater than 0.25 (40 out of 58 present) are shown for 10 renal cancer metastasis samples. The genes can be divided into two groups, those that lose their renal cancer-specific expression (blue) and those that do not (red). The samples are named according to where the metastasis was located, and numbered according to their (relative to each other) similarity to renal cancer. Sample 10 was the only one whose closest similarity was not renal cancer, it instead being lung squamous cell carcinoma. Samples 1 to 3 are the closest to renal cancer, and retain for most of the genes renal cancer-specific expression levels. The other samples have lost renal cancer-specific expression among the genes with a blue background. (b) Similar analysis for the 17 metastatic melanoma samples, showing 42 (out of 63) genes. (c) Similar analysis for 10 metastatic gastric cancer samples, showing 40 (out of 53) genes.

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