Regulators
|
Function
|
Methods
|
Reference(s)
|
---|
Core factors
| | | |
Oct4 (Pou5f1)
|
ES cell core factor
|
ChIP, MS
|
[27–32, 44]
|
Sox2
|
ES cell core factor
|
ChIP, MS
|
[28, 32, 44]
|
Nanog
|
ES cell core factor
|
ChIP, MS
|
[27–29, 32, 44]
|
Tcf3 (Tcf7l1)
|
Wnt signaling
|
ChIP
|
[74]
|
Klf4
|
LIF signaling
|
ChIP
|
[32, 44]
|
Stat3
|
LIF signaling
|
ChIP
|
[44]
|
Dax1 (Nr0b1)
|
Negative regulation of transcription
|
ChIP, MS
|
[29, 32]
|
Sall4
|
Self-renewal and pluripotency
|
ChIP, MS
|
[29, 75–77]
|
Polycomb-related factors
| | | |
Ezh2
|
PRC2, repressor
|
ChIP, MS
|
[78, 79]
|
Jarid2
|
Fine-tuning of PRC2
|
ChIP, MS
|
[78, 79]
|
Mtf2
|
Polycomb-like protein
|
ChIP, MS
|
[78]
|
Suz12
|
PRC2, repressor
|
ChIP, MS
|
[37, 38, 78, 79]
|
Eed
|
PRC2, repressor
|
ChIP
|
[37, 38]
|
Rnf2
|
PRC1, repressor
|
ChIP
|
[37]
|
Phc1
|
PRC1, repressor
|
ChIP
|
[37]
|
Myc-related factors
| | | |
Myc
|
Proliferation
|
ChIP, MS
|
[20, 44]
|
Max
|
Myc-interacting
|
ChIP, MS
|
[20]
|
Zfx
|
Self-renewal
|
ChIP
|
[44]
|
Trrap
|
Histone acetylation
|
RNAi
|
[50]
|
Tip60 (Kat5)
|
Histone acetylation
|
ChIP, MS, RNAi
|
[20, 50]
|
Ep400
|
Histone acetylation
|
MS, RNAi
|
[50]
|
Dmap1
|
Histone acetylation
|
ChIP, MS, RNAi
|
[20, 50]
|
E2F1
|
Regulator of cell cycle
|
ChIP
|
[44]
|
E2F4
|
Transcription activator
|
ChIP, MS
|
[20]
|
Cnot3
|
General transcription regulator
|
ChIP, RNAi
|
[80]
|
Trim28 (Tif1b)
|
Transcription co-activator
|
ChIP, RNAi
|
[80]
|
- LIF, leukemia inhibitory factor.