Table 2 Studies of embryonic stem cell signatures in cancer
Study | Gene sets used in the study | Gene set generated by: | Tested cancers |
|---|---|---|---|
Ben-Porath et al. [23] | ES cell expression profiles, Nanog, Oct4, Sox2 targets, Myc targets, and PRC targets | ES-cell-specific gene expression, and factor occupancy | Breast, glioma, and bladder cancers |
Wong et al. [22] | ES-cell-like module, adult stem cell module | Gene module map [81] | Liver, breast, prostate, gastric, and lung cancers |
Schoenhals et al. [26] | Nanog, Oct4, Sox2, and Klf4 | ES-cell-specific gene activity in multiple cancers | Multiple cancers |
Kim et al. [20] | Core module, PRC module, and Myc module | Factor co-occupancy within transcription sub-networks | Myeloid/lymphoid leukemia, bladder and breast cancers |
Mizuno et al. [25] | ES cell, iPS cell, PRC2, and p53 ES cell signatures | Gene expression profiles | Breast cancer |
Shats et al. [24] | CSR signature | Combined gene sets | Breast and lung cancers, adenocarcinoma, and medulloblastoma |