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Table 1 Potential contribution of pharmacogenetic approaches

From: Pharmacogenetics in type 2 diabetes: potential implications for clinical practice

Advantage Explanation
Discovery of new drug targets Agnostic genome-wide approaches are not contingent on prior biological knowledge
Mechanistic insight Discoveries of new pathways may illuminate the pathophysiology of the disease process that is targeted by a given drug
Nosology of disease Understanding of molecular pathways can help explain disease heterogeneity and classify its various subtypes
Fine-mapping Detecting a drug-gene interaction can pinpoint the specific gene under a genomic association signal that is likely to harbor the causal genetic variant
Personalized medicine Genetic determinants of drug response may result in individualized approaches to therapy based on the likelihood of effectiveness and tolerance