Drug control over the p38 pathway. (a) Kaplan-Meier curves generated according to the treatment profiles of the patients. Group 2 (green line), which is associated with better prognosis, consists of 63 patients who received one of the six drugs that target genes in the p38/MAPKAP pathway. Group 1 (blue line), which is associated with poorer prognosis, consists of 169 patients, none of whom received any of the six drugs. (b) The p38 signaling network. Genes highlighted with red boxes are those targeted by the six drugs (also see Table 2).