Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model

Table 2 Using the zebrafish model for gene/protein or small-molecule discovery relevant to human blood disorders

Zebrafish mutant (protein or small molecule)	Human disorder or potential therapeutic application	Known function	Discovery
weissherbst* (ferroportin)	Hemochromatosis	Iron export^†‡	[21]
frascati* (frs) (mitoferrin)	Hypochromic anemia	Iron assimilation^†‡	[22]
shiraz* (sir) (glutaredoxin 5)	Hypochromic anemia	Assembly of Fe-S cluster^†‡	[23]
Dimethyl prostaglandin E2	Bone marrow transplant therapy (clinical trial)	Enhanced HSC engraftment^†	[45]
3F8	GSK3 implicated in type II diabetes, bipolar disorder, Alzheimer's disease, some cancers	Inhibits GSK3^†	[47]
Thiazole-carboxamide 10A	PLK1 upregulated in many cancers	Inhibits PLK1^†	[81]

GSK3, glycogen synthase kinase 3; HSC, hematopoietic stem cell; PLK1, polo-like kinase 1. *Three hematopoietic mutations originally identified in zebrafish have since been linked to human genetic mutation and disease (see text for details). ^†Known function in zebrafish. ^‡Known function in humans.

ISSN: 1756-994X