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Table 2 Using the zebrafish model for gene/protein or small-molecule discovery relevant to human blood disorders

From: Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model

Zebrafish mutant (protein or small molecule) Human disorder or potential therapeutic application Known function Discovery
Hemochromatosis Iron export†‡ [21]
frascati* (frs)
Hypochromic anemia Iron assimilation†‡ [22]
shiraz* (sir)
(glutaredoxin 5)
Hypochromic anemia Assembly of Fe-S cluster†‡ [23]
Dimethyl prostaglandin E2 Bone marrow transplant therapy (clinical trial) Enhanced HSC engraftment [45]
3F8 GSK3 implicated in type II diabetes, bipolar disorder, Alzheimer's disease, some cancers Inhibits GSK3 [47]
Thiazole-carboxamide 10A PLK1 upregulated in many cancers Inhibits PLK1 [81]
  1. GSK3, glycogen synthase kinase 3; HSC, hematopoietic stem cell; PLK1, polo-like kinase 1. *Three hematopoietic mutations originally identified in zebrafish have since been linked to human genetic mutation and disease (see text for details). Known function in zebrafish. Known function in humans.