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Figure 1 | Genome Medicine

Figure 1

From: The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls

Figure 1

Exonic-intronic structure of splice forms and domain representation of PTPN22. A genomic illustration of PTPN22 in human chromosome 1p32. Hs00247352_m1 and Hs00249262_m1 are assay numbers (Applied Biosystems). The four SRC homology 3 (SH3) domains are denoted by P1 to P4 and are typically involved in protein-protein interaction. Known binding sites for carboxy-terminal Src kinase (Csk) and CD2-binding protein 1 (CD2BP1) are located in P2 and P4 (carboxy-terminal homology (CTH) domain), respectively. The carboxyl terminus of Lyp1 contains a consensus motif for cyclin-dependent kinase 1 (CDK1). The exonic and basic domain structure is deduced from Ensembl (Ensembl 64, September 2011) [30] and UCSC Genome Browser (GRCh37/hg19 assembly) [31] and published articles [3, 12].

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