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Table 1 Expression of PTPN22 transcripts in peripheral blood mononuclear cells from cohorts I, II and III

From: The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls

 

Median relative quantity values

 
 

Control group

RA patient group

P-valuea

Cohort I

n = 44

n = 44

 

   PTPN22_v4

1.05

0.85

0.08

   PTPN22-long

1.03

1.20

0.006

   long/v4b

1.01

1.42

6 × 10-9

Cohort II

n = 19

n = 47

 

   PTPN22_v4

0.98

0.96

0.85

   PTPN22-long

0.97

1.07

0.25

   long/v4b

0.96

1.15

0.02

Cohort III

n = 48

n = 48

 

   PTPN22_v4

0.96

0.72

1.2 × 10-4

   PTPN22-long

0.97

0.92

0.2

   long/v4b

1.04

1.24

0.01

  1. aP-value for comparison of rheumatoid arthritis (RA) patient group and control group, Mann-Whitney test. bThe ratio of PTPN22-long and PTPN22_v4 was calculated for each sample separately.