Upregulation or downregulation |
Sample/material studied | Reference(s) | |
---|---|---|---|
DNA methylation | |||
Genome-wide | Down | Tumors | [60, 62] |
Repetitive elements (LINE-1, SAT-2, ALU) | Down | Tumors | [61] |
p16INK4A (TSG) | Up | Cirrhotic tissue, blood, serum, tumors | [59, 63, 86] |
RASSF1A (TSG) | Up | Cell lines, cirrhotic tissue, serum, tumors | [59, 63, 86] |
SOCS1 (TSG) | Up | Cell lines, tumors | [55, 59, 63, 102] |
E-Cadherin (TSG) | Up | Cirrhotic tissue, tumors | [63, 86] |
GSTP1 (TSG) | Up | Serum, tumors | [59, 63, 86] |
Histone mark | |||
H3K9 dimethylation | Up | Cell lines | [69] |
H3K9 trimethylation | Up | Rodent models | [68] |
H3K27 trimethylation | Up | Cell lines | [69] |
H4K20 trimethylation | down | Rodent models | [68] |
H3 global acetylation | Down and up | Cell lines | [70] |
H4 global acetylation | Down and up | Cell lines | [70] |
microRNA | |||
miR-1 | Down | Cell lines, tumors | [73, 77] |
miR-18 | Up | Tumors | [72, 75, 138] |
miR-21 | Up | Cell lines, tumors | [72–74, 138] |
miR-122 | Down | Tumors | [73, 77, 81, 138] |
miR-199 | Down | Tumors | [73–76, 138] |
miR-221 | Up | Cell lines, tumors | [73, 74, 77, 79, 81, 138] |
miR-222 | Up | Cell lines, tumors | [77, 79] |
miR-224 | Up | Tumors | [75, 78, 138] |