Skip to main content

Advertisement

Table 2 Epigenetic deregulation in hepatocellular carcinoma

From: From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms

  Upregulation or downregulation Sample/material studied Reference(s)
DNA methylation
Genome-wide Down Tumors [60, 62]
Repetitive elements (LINE-1, SAT-2, ALU) Down Tumors [61]
p16INK4A (TSG) Up Cirrhotic tissue, blood, serum, tumors [59, 63, 86]
RASSF1A (TSG) Up Cell lines, cirrhotic tissue, serum, tumors [59, 63, 86]
SOCS1 (TSG) Up Cell lines, tumors [55, 59, 63, 102]
E-Cadherin (TSG) Up Cirrhotic tissue, tumors [63, 86]
GSTP1 (TSG) Up Serum, tumors [59, 63, 86]
Histone mark
H3K9 dimethylation Up Cell lines [69]
H3K9 trimethylation Up Rodent models [68]
H3K27 trimethylation Up Cell lines [69]
H4K20 trimethylation down Rodent models [68]
H3 global acetylation Down and up Cell lines [70]
H4 global acetylation Down and up Cell lines [70]
microRNA
miR-1 Down Cell lines, tumors [73, 77]
miR-18 Up Tumors [72, 75, 138]
miR-21 Up Cell lines, tumors [7274, 138]
miR-122 Down Tumors [73, 77, 81, 138]
miR-199 Down Tumors [7376, 138]
miR-221 Up Cell lines, tumors [73, 74, 77, 79, 81, 138]
miR-222 Up Cell lines, tumors [77, 79]
miR-224 Up Tumors [75, 78, 138]
  1. TSG, tumor suppressor gene.