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Table 1 Summary of loci associated with variation in adult BMI in two large GWASs

From: Narrowing down the role of common variants in the genetic predisposition to obesity

   Odds ratio (95% CI) of obesity in adults  
Chromosome Genes GIANT deCODE Relevant tissue expression and/or function
1p31 NEGR1 1.05 (1.01-1.11) 1.07 (1.02-1.12) Adipose
1q25 SEC16B, RASAL2   1.11 (1.05-1.18) Liver
2 TMEM18 1.19 (1.11-1.26) 1.20 (1.13-1.27)  
3 ETV5, SFRS10, DGKG   1.11 (1.05-1.17)  
4 GNPDA2 1.12 (1.07-1.17)   Adipose
6p21 NCR3, AIF1, BAT2   1.07 (1.02-1.12) Hypothalamus; NCR3 also adipose
11p14 BDNF, LGR4, LIN7C   1.12 (1.06-1.19) BDNF: hypothalamus; humans with BDNF deletion are obese, and knockdown in mouse hypothalamus leads to obesity
    1.11 (1.05-1.16)  
11p11 MTCH2 1.03 (0.98-1.08)   Adipose, hypothalamus and liver
12 FAIM2, BCDIN3D   1.14 (1.09-1.19) Adipose, hypothalamus and liver
16p11 SH2B1, ATP2A1 1.11 (1.06-1.17) 1.08 (1.03-1.13) SH2B1: adipose and hypothalamus; null mice are obese
16q12 FTO, RPGRIP1L 1.25 (1.19-1.31) 1.27 (1.21-1.32) FTO: adipose and hypothalamus
    1.16 (1.10-1.21)  
18q21 MC4R 1.15 (1.08-1.21) 1.12 (1.06-1.17) Hypothalamus; associated with obesity in humans, and MC4R deficient mice are obese
19 KCTD15, CHST8 1.04 (0.98-1.10) 1.10 (1.04-1.15) Adipose and hypothalamus
  1. Gene name abbreviations: AIF1, allograft inflammatory factor 1; ATP2A1, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; BAT2, HLA-B associated transcript 2; BCDIN3D, BCDIN3 domain containing; BDNF, brain-derived neurotrophic factor; CHST8, carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; DGKG, diacylglycerol kinase, gamma 90 kDa; ETV5, ets variant 5; FAIM2, Fas apoptotic inhibitory molecule 2; FTO, fat mass and obesity associated; GNPDA2, glucosamine-6-phosphate deaminase 2; KCTD15, potassium channel tetramerisation domain containing 15; LGR4, leucine-rich repeat-containing G protein-coupled receptor 4; LIN7C, in-7 homolog C; MC4R, melanocortin 4 receptor; MTCH2, mitochondrial carrier homolog 2; NCR3, natural cytotoxicity triggering receptor 3; NEGR1, neuronal growth regulator 1; RASAL2, RAS protein activator like 2; RPGRIP1L, RPGR-interacting protein 1-like protein; SEC16B, SEC16 homolog B (Saccharomyces cerevisiae); SFRS10, splicing factor, arginine/serine-rich 10; SH2B1, SH2B adaptor protein 2; TMEM18, transmembrane protein 18. CI, confidence interval.