Narrowing down the role of common variants in the genetic predisposition to obesity

Table 1 Summary of loci associated with variation in adult BMI in two large GWASs

		Odds ratio (95% CI) of obesity in adults
Chromosome	Genes	GIANT	deCODE	Relevant tissue expression and/or function
1p31	NEGR1	1.05 (1.01-1.11)	1.07 (1.02-1.12)	Adipose
1q25	SEC16B, RASAL2		1.11 (1.05-1.18)	Liver
2	TMEM18	1.19 (1.11-1.26)	1.20 (1.13-1.27)
3	ETV5, SFRS10, DGKG		1.11 (1.05-1.17)
4	GNPDA2	1.12 (1.07-1.17)		Adipose
6p21	NCR3, AIF1, BAT2		1.07 (1.02-1.12)	Hypothalamus; NCR3 also adipose
11p14	BDNF, LGR4, LIN7C		1.12 (1.06-1.19)	BDNF: hypothalamus; humans with BDNF deletion are obese, and knockdown in mouse hypothalamus leads to obesity
			1.11 (1.05-1.16)
11p11	MTCH2	1.03 (0.98-1.08)		Adipose, hypothalamus and liver
12	FAIM2, BCDIN3D		1.14 (1.09-1.19)	Adipose, hypothalamus and liver
16p11	SH2B1, ATP2A1	1.11 (1.06-1.17)	1.08 (1.03-1.13)	SH2B1: adipose and hypothalamus; null mice are obese
16q12	FTO, RPGRIP1L	1.25 (1.19-1.31)	1.27 (1.21-1.32)	FTO: adipose and hypothalamus
			1.16 (1.10-1.21)
18q21	MC4R	1.15 (1.08-1.21)	1.12 (1.06-1.17)	Hypothalamus; associated with obesity in humans, and MC4R deficient mice are obese
19	KCTD15, CHST8	1.04 (0.98-1.10)	1.10 (1.04-1.15)	Adipose and hypothalamus

Gene name abbreviations: AIF1, allograft inflammatory factor 1; ATP2A1, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; BAT2, HLA-B associated transcript 2; BCDIN3D, BCDIN3 domain containing; BDNF, brain-derived neurotrophic factor; CHST8, carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; DGKG, diacylglycerol kinase, gamma 90 kDa; ETV5, ets variant 5; FAIM2, Fas apoptotic inhibitory molecule 2; FTO, fat mass and obesity associated; GNPDA2, glucosamine-6-phosphate deaminase 2; KCTD15, potassium channel tetramerisation domain containing 15; LGR4, leucine-rich repeat-containing G protein-coupled receptor 4; LIN7C, in-7 homolog C; MC4R, melanocortin 4 receptor; MTCH2, mitochondrial carrier homolog 2; NCR3, natural cytotoxicity triggering receptor 3; NEGR1, neuronal growth regulator 1; RASAL2, RAS protein activator like 2; RPGRIP1L, RPGR-interacting protein 1-like protein; SEC16B, SEC16 homolog B (Saccharomyces cerevisiae); SFRS10, splicing factor, arginine/serine-rich 10; SH2B1, SH2B adaptor protein 2; TMEM18, transmembrane protein 18. CI, confidence interval.

ISSN: 1756-994X