Table 1 AMD classification scheme
AMD classification | Alternative name | AREDS level [42] | Rotterdam grade [41] | Description | Donors per classa |
|---|---|---|---|---|---|
Normal | Â | 1 | 0a | No features of AMD | 31 |
MD1 | Pre-AMD | 1 | 0b | Hard macular drusen (< 63 μm) only | 7 |
MD2 | Sub-clinical pre-AMD | 2 | 1a | Soft, distinct macular drusen (> 63 μm) | 4 (1a only) |
| Â | Â | Â | 1b | Macular pigmentary irregularities without soft drusen | Â |
Dry AMD | Dry AMD (non-GA) | 3, 4b | 2a | Soft, indistinct (> 125 μm) or reticular macular drusen | 17 |
|  |  |  | 2b | Soft distinct macular drusen (> 63 μm) with pigmentary changes | 17 |
| Â | Â | Â | 3 | Soft indistinct macular drusen with pigmentary changes | 17 |
GA | Geographic atrophy | 4a | 4 | Sharply demarcated area of apparent absence of the RPE (> 175 μm) involving central macular region | 2 |
CNV | Wet AMD | 4a | 4 | Sub-retinal choroidal neovascularization | 4 |
GA/CNV | Â | 4a | 4 | Geographic atrophy with choroidal neovascularization | 3 |