EVORA AUC values as a function of differential variability and PCGT status. (a, b) Comparison of EVORA AUC measures for four different CpG classes in (a) set 1 consisting of 18 CIN2+ LBC samples and 30 normal LBC samples, and in (b) set 2 consisting of 48 cervical cancers and 15 cervical normal tissues. Of the 140 risk CpGs, 69 mapped to PCGTs (risk-PCGT class) and 71 did not (risk-nonPCGT class). In addition, we randomly selected 70 non-differentially variable, non-age-associated CpGs (nonrisk) that mapped and that did not map to PCGTs. The random selection was done 100 times and AUC values averaged. Also provided are 95% confidence intervals.