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Table 2 Potential targets for premarital carrier screening in Arabic LMICs

From: Next-generation community genetics for low- and middle-income countries

Disease Inheritance OMIM no. Carrier frequency in Arab populations [35, 55]
Sickle cell disease AR 603903 0.3% to 30%
Beta-thalassemia AR 613985 2% to 7%
Alpha-thalassemia AR 604131 2% to 50%
Cystic fibrosis AR 219700 1/25 to 1/50
Spinal muscular atrophy AR 253300 1/25 to 1/60
  1. AR, autosomal recessive; LMICs, low- and middle-income countries; OMIM, Online Mendelian Inheritance in Man [54].